Neuroendocrine carcinoma of the prostate
Neuroendocrine Prostate Cancer. Androgen signaling is a critical player in prostate cancer progression. Testosterone is needed for prostate cancer as a fuel; testosterone interacts with the androgen receptor, which is necessary for transcription within the prostate cancer cells.NEW YORKNeuroendocrine prostate cancer is a highrisk, lethal subset of disease, often referred to as representing only two percent of all diagnosed prostate cancer. neuroendocrine carcinoma of the prostate
In prostate cancer, neuroendocrine (NE) differentiation is believed to occur in response to androgen ablation, and NE paracrine factors have been shown to stimulate growth of androgenindependent cancer cells [2 x [2 Abrahamsson, P. A. Neuroendocrine differentiation in prostatic carcinoma.
mall cell prostate carcinoma (SCPC) is a rare form of extrapulmonary highgrade neuroendocrine carcinoma accounting for 0. 5 to 1 of all prostate cancers (1). Statistics. Primary neuroendocrine carcinoma is very rare and accounts for less than 5 of prostate cancers. More frequently, small sections of neuroendocrine carcinoma occur within the far more common adenocarcinoma form. This occurs because cancer cells are rapidly changing and dividing and tend to change their form.neuroendocrine carcinoma of the prostate Small cell prostate carcinoma (SCPC) is a rare form of extrapulmonary highgrade neuroendocrine carcinoma accounting for 0. 5 to 1 of all prostate cancers (1). It is characterized by an aggressive clinical course and portends a poor prognosis. Locally advanced or metastatic disease is common at the time of presentation.
Abstract. Neuroendocrine (NE) differentiation in tumors of the prostate or in the setting of prostate cancer (PCa) is rare. A survey of these lesions is presented, including usual PCa with focal NE markerpositive cells, Paneth celllike change, prostatic carcinoid, highgrade NE carcinoma, as well as other tumors that do not fit neatly neuroendocrine carcinoma of the prostateRating: 4.95 / Views: 718